Gene diagnosis and oncogenes of leukemia.
نویسندگان
چکیده
منابع مشابه
[Gene diagnosis and oncogenes of leukemia].
1。Philadelphia(Pぬ り 染 色体 と白血病 Ph1染 色 体 を有 す る 白 血 病 は 慢 性 骨 髄 性 白血 病 (CML),急 性 リソバ性 白血病(ALL),急 性骨髄 性 白 血病(AML)が あ り,白 血病 に特異 的な染 色体異常 で あ る.CMLで は95%の 頻 度でALLで は20%,AML で は5%程 度 にPh三 染色体 陽性 白血病 が存 在す る.こ のPh1染 色 体 は染 色体9番 と22番 の転 座 に よる転座 22番 染色体 を さ して いる.CMLの 症 例で は,こ のPh1 染色体 はDNAレ ベ ルで9q34に 位置 す るabl癌 遺伝 子が22q11のbreakpointclusterregion(bcr)と 呼 ば れ る5.8kbの 領 域 内 の 切 断 点 に 転 座 して い る (malorbr...
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ژورنال
عنوان ژورنال: Journal of Nippon Medical School
سال: 1991
ISSN: 0048-0444,1884-0108
DOI: 10.1272/jnms1923.58.708